HORDB

ID: hor004355
Uniprot ID: Q868G6
Protein name: NPRWEFRGKFVGVR-amide
Gene name: Atk
Organism: Apis mellifera (Honeybee)
Family: Tachykinin family
Source: animal
Expression: Strong expression was detected in the queen and forager heads, while weak and almost no significant expression was detected in the nurse and drone heads, respectively.
Disease: NA
Comments: NA
Taxonomy: Apis (genus), Apini (tribe), Apinae (subfamily), Apidae (family), Apoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007610 behavior
GO CC: GO:0005576 extracellular region; GO:0045202 synapse

Sequence: NPRWEFRGKFVGVR
Length: 14
Propeptide: MIIHSIFLLMVSITLVIAEESDNVLFDKRAPTGHQEMQGKQNSASLNSENFGIFKRALMGFQGVRGKKNSIINDVKNELFPEDINKRAPMGFQGMRGKKASFDDEYYKRAPMGFQGMRGKKSLEEILDEIKKKTTRFQDSRSKDVYLIDYPEDYGKRVLSMDGYQNILDKKDELLGEWEKRAPMGFYGTRGKKIILDALEELDKRGVMDFQIGLQRKKDTTFDDYLDYAINPFDYEKRSTDFQDVESGSESFKRARMGFHGMRGKRDAAGIYGSNSSTVGTIFGYQDMRNRGNNFPVYQVEKRSPFRYLGARGKKNPRWEFRGKFVGVRGKKSSLQTVF
Signal peptide: MIIHSIFLLMVSITLVIA
Modification: T14 Arginine amide
Glycosylation: NA
Mutagenesis: NA

Function: Be active peptides which excite neurons, evoke behavioral responses, be potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P01303-F1.pdb

hor004355_AF2.pdb

hor004355_ESM.pdb

Mass:	198006	Formula:	C81H122N26O18
Absent amino acids:	ACDHILMQSTY	Common amino acids:	R
pI:	12.22	Basic residues:	4
Polar residues:	3	Hydrophobic residues:	5
Hydrophobicity:	-97.86	Boman Index:	-4551
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	41.43
Instability Index:	2456.43	Extinction Coefficient cystines:	5500
Absorbance 280nm:	423.08

PubMed ID: 17068263
Title: From the Genome to the Proteome: Uncovering Peptides in the Apis Brain